New sensor will allow continuous monitoring of key health indicators

Researchers from the Biomedical Engineering and Applied Physics Departments of the Technical University

Eindhoven came up with a new approach to detecting low-mass molecules of interest. They are used to monitor the general physical condition of a person.

Junhong Yang, Menno Prince and colleaguesdemonstrate a novel approach that can continuously measure the concentration of low-mass molecules of interest in samples based on biosensing by particle mobility (BPM) analysis.

Existing biosensors usually provide onemeasurement result for one biological sample. The sample can be blood, sweat, urine, or saliva, and the result can be the level of protein, hormone, drug, or virus in the sample.

However, it would be better if the sensors provided a continuous stream of data, which would allow a person to track how the disease develops over time.

Each biosensor consists of three main parts:

  • a molecular component with a bioreceptor that can bind to a molecule of interest,
  • a transformation principle that converts molecular recognition into a detectable signal,
  • a detection system that records a signal and presents a response in the form of a numerical, graphic, sound or light indication, which is easy for the user to interpret.

“In this work, we focused on the first part- the development of a molecular principle for continuous measurement of molecules of interest with low molecular weight and low concentration, "explains one of the authors of the development.

The sensor, developed by Ian, Prince and team, adapted the use of molecular twins or fake versions of the molecules of interest.

Eindhoven University of Technology

How These Similar Molecules Help Detectreal molecules? The surface of the sensor is coated with antibodies that can bind to molecules of interest. When there are no molecules in the test liquid, similar molecules can freely bind to antibodies. However, when molecules of interest are found, they can bind to antibodies. As a result, the doubles are freed from "work".

The touch platform operation is quite simple and,I must say, brilliant. All molecular binding events must be reversible. This includes binding between antibodies and twins, as well as binding between antibodies and molecules of interest in solution.

Duplicate binding events occur andunbinding involving similar molecules or molecules of interest in a liquid, and these events can be easily measured with optical microscopy by recording the state of a microparticle.

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