New tool more accurately identifies cancer and Alzheimer's risks

Chemists at the University of Albert (Canada) have developed new tools to study the immune system

human. In the future, they may lay the foundation for research that will identify cancer and Alzheimer's early on.

“Our laboratory studies sugar receptors underthe name Siglecs, which control the cells of our immune system, - said scientist Matthew McAuley. "Studying the sugar properties of Siglecs is challenging because these biochemical interactions are weaker than typical interactions in the body."

To solve this problem, researchthe group used an effect that amplifies interactions, making them easier to learn. The researchers note that these advances facilitate our understanding of the role that Siglecs play in neurodegeneration and cancer.

New nanomaterial acts like a molecular thermometer

Research team applied new toolsto study CD33 proteins. The researchers speculate that they may play a role in preventing immune cells from removing toxic molecules in the brain. “Using new tools, we were able to clarify the biochemical nature of CD33, which turned out to be broader than previously thought,” the researchers noted.

“Some people in the population have the CD33 version,which cannot recognize sugar, and these people are less likely to develop Alzheimer's. The consequence of this is that the interactions between CD33 and sugars are harmful. Ultimately, a better understanding of sugars and CD33 may lead to the development of a strategy to target the interaction of CD33 with sugar as a treatment for disease. ”

“The tools were designed in such a wayto be compatible with many different testing methods, including mass spectrometry. This work opens up many new possibilities for studying these receptors, ”the scientists noted.

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