It is impossible to predict in what form a person will tolerate COVID-19: severe or mild. Doctors still have not
Researchers at Beth Israel Medical CenterDeaconess in Boston, led by Robert Gerszten, M.D., head of the center's cardiovascular medicine department and a professor at Harvard Medical School, decided to link the severe course of the coronavirus and the features of the gene structure.
COVID-19 patients show a wide spectrumclinical manifestations - from flu symptoms to acute respiratory infections. It is known that cardiovascular and metabolic diseases are risk factors, but it is not clear why some people have a life-threatening illness and some do not.
The authors examined the genomes of 4,856 patients fromCOVID-19 survivors from China, Europe and the United States found variations in the two regions that determine the severity of the disease. They then identified which proteins encode these regions of the genome and what role these proteins play in the body in the context of disease.
It turned out that one of the two regions of the genome wasassociated with the CD209 antigen. It is a protein by which the coronavirus penetrates and infects human cells. Another point was related to the poorly understood protein CXCL16, which scientists believe helps to distribute immune cells to sites of infection.
The authors believe their work will help better understand how to deal with a new disease.
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