An experimental vaccine has driven Salmonella bacteria into an evolutionary dead end

Bacteria are living examples of evolution in action. Darwin's classical theory states that when life forms

under pressure from the environment, some of them develop new genetic mutations. Eventually, they will become the norm for the entire population.

In the world of bacteria and viruses, drugs and vaccines areit is the environmental pressure that they have to overcome. And they do it with depressing ease, quickly finding ways to bypass attacks and then exploiting those genes. The end result is the constant threat of the emergence of antibiotic-resistant superbugs.

So researchers at ETH Zurich, instead of developing a drug that kills bacteria, found a way to make the bacteria safe by driving them into an evolutionary dead end.

To begin with, scientists injected mice with several differentvaccines against Salmonella typhimurium (Salmonella). Biologists then observed how bacteria in the intestines of animals develop drug resistance. In the end, the scientists combined all the variants of Salmonella after the mutation and made a vaccine and changed the bacterium. She is still able to live in the body and reproduce, but not infect humans.

Scientists are confident that the new method can be usedto develop vaccines against antibiotic-resistant bacteria, and perhaps even to eradicate some dangerous strains in a manner similar to how smallpox was eradicated.

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