A cellular atlas of COVID-19 pathologies has been created

Scientists have shown what happens in the individual cells of patients who died fromCOVID-19.In the study,

published inNature magazine, the authors of the work describe how infectedcells from multiple organs exhibit a range of molecular and genomic changes. Scientists also saw signs of multiple unsuccessful attempts by the lungs to recover in response to respiratory failure. It is she who is the main cause of death of patients with COVID-19.

We are grateful to the patients and their families who agreed to donate tissue to COVID-19 research to help better understand this devastating disease.

Aviv Regev, co-author of the study

The team investigated how the SARS-CoV-2 virus affectson the functions of cells and their genetic programs. They used single-cell RNA sequencing data from tissue samples taken from 11 organ systems. Material from the lungs, heart, liver and kidneys was used to build a comprehensive "cell atlas" of hundreds of thousands of individual cells showing how COVID-19 can lead to multiple organ failure and death.

The cell atlas team is located infree and open access for study by other scientists. The authors of the project also created a biobank of 420 samples from deceased patients, which can be used for other COVID-19 research.

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