A technology has been created for the careful preservation of organs. Cryoagents do not harm cells

Australian researchers showed that a cryoprotectant with two agents, proline and glycerol, proved

effective for storing various types of cells, including skin and brain. At the same time, long-term incubation of the samples before freezing in such a solution did not harm them.

Researchers explain that for manyFor years, two main substances have been used for cryopreservation of cells: dimethyl sulfoxide and glycerol. This technology has made a lot of discoveries in medicine (for example, IVF and stem cell therapy), but its possibilities are limited. Both of these substances are toxic and only suitable for freezing certain types of cells.

In his work, published in the Journal ofMaterials Chemistry B, the researchers tested the possibility of using various eutectic solvents as cryoagents. The study showed that a solution of proline and glycerol can be used to preserve other cells. In addition, such a cryoprotectant turned out to be more effective and less toxic than individual components.

Researchers have found that long-termincubation of cells with the new cryoprotectant at 37°C does not harm the cells. This, as the authors of the work explain, is important for the conservation of organs: tissues can be in solution for a long time so that not only the outer layers, but also the inner cells are saturated with a protective substance.

The researchers believe that the discovery will serve as the basis for the creation of new cryoprotective substances that will be able to maintain the viability of donor organs for many years, not hours.

Cover image: Saffron Bryant, RMIT University

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