Neural network trained to look for left-handed DNA

Previously, scientists believed that all DNA molecules are spirals twisted to the right, but after

after analyzing the genome, it turned out that this was not always the case.

Some parts of the chromosomes are twisted to the left.called Z-DNA, and those that are twisted to the right B-DNA. Understanding which way the chromosomes are twisted is important, as this can be the cause of diseases such as cancer, diabetes and Alzheimer's.

However, in the diagnosis of the spiral shape, there aredifficulties: scientists do not yet have an exact idea of ​​how often such segments are found inside chromosomes, what controls their formation and how their structure can change over time. This is due to both the large size of the genome and the difficulties in finding sections of Z-DNA.

In order to simplify this task, Russianbioinformatics. In order to train her, they used information about already known gene regions, as well as data on how gene activity and protein synthesis in cells are regulated.

The most efficient model based on this typeScientists have used neural networks to predict where yet unknown sections of Z-DNA may be located in the human genome. Bioinformatics hope that they will soon be able to test predictions and use such data to study the role that Z-DNA plays in the body.

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