Previously, attempts to create such chimeras ended in vain, because human cells in such embryos
The success of the new experiment was that the authors created a new technology that made it possible to maintain the life of chimeric monkey embryos outside their body for a long period of time.
Formation of chimeras with non-human primatesmore closely related to humans on an evolutionary scale than any previously used species will provide a better understanding of whether there are barriers to hybrid formation and whether there are ways in which they can be overcome.
Juan Carlos Izpisua Belmonte, Professor at the Gene Expression Laboratory of the Salk Institute
On the sixth day of the existence of monkey embryosMacaca fascicularis developing ex vivo, the authors introduced into each of them 25 human stem cells from an induced pluripotent cell line. These cells can participate in the formation of both embryonic and extraembryonic tissues.
On the sixth day of the existence of Macaca fascicularisbiologists introduced into each of them 25 human stem cells from an induced pluripotent cell line. Such cells can participate in the formation of both embryonic and extraembryonic tissues. A day later, human cells were found in 132 embryos, after 10 days 103 chimeric embryos still continued to develop, and only three chimeras remained alive by the 19th day.
Scientists hope that such chimeric embryos can be used for research that is ethically problematic in humans.
The authors are going to find out in the near future what exactly prevents human cells from dividing in hybrid embryos.
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