Researchers at Tufts University have created a new mRNA cancer vaccine that is designed to
Biologists have improved the immune response by changing the route and"destination" mRNA in the body. In most cases, the mRNA ends up in the liver, but a more effective immune response can be obtained by sending the molecules to the lymphatic system, where immune cells are better trained to recognize intruders.
To do this, scientists have changed the recipe for lipidnanoparticles that transport mRNA. This caused different molecules from the bloodstream to collect on the surface of the particles, which in turn bind to receptors in different organs. After testing several combinations of properties, the biologists created lipid nanoparticles that promoted delivery to the lymph nodes compared to the liver by a ratio of three to one.
There, the vaccine was absorbed by about a third of the dendriticcells and macrophages. These key immune cells train B and T cells to target specific antigens, resulting in a stronger immune response against cancer.
Tests on mice with metastatic melanomashowed that the treatment significantly inhibited tumors when combined with another treatment, anti-PD-1 therapy. Moreover, complete remission occurred in 40% of cases, and the cancer did not recur in the future. Even after scientists later injected them with metastatic tumor cells. Thus, scientists not only cured cancer, but also "hardened" the organisms of experimental animals.
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