Scientists have finally explained why poor sleep is linked to chronic pain. New study on mouse mice
Pyramidal neurons are the main excitatory neuronsmammalian brain neurons. Also found in fish, birds, and reptiles. They resemble a pyramid in shape, from which a large apical dendrite leads upward; have one axon and many basal dendrites.
It turned out that the shift in brain activity wasassociated with changes in pain sensitivity in mice. Once painless stimuli led to its occurrence. In a series of experiments, researchers found that they could alleviate it by blocking the hyperactivity of various cells in brain pathways.
“Inhibition of these pathways during NREM sleep, but not wakefulness, corrects neuronal hyperactivation and relieves pain,” the scientists explain.
People with chronic pain often experiencesleep disorders, including insomnia, and evidence suggests that poor sleep quality is primarily a major risk factor for developing chronic pain. Although the link is well known, the nature of sleep problems in various pain conditions, their exact causes or long-term effects are still unknown.
Nerve circuit remodeling during sleep plays a vital role in the formation of chronic pain, and this is very relevant for the development of new painkillers.
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