Existing therapeutic methods for restoring sinus rhythm in symptomatic fibrillation
Local delivery to the right atrium of adeno-associated viral vectors encoding a light-guided depolarization ion channel leads toto efficient and spatially limited transgene expression.
Adeno-associated virusis a small virus that infects human cells and some other primates.It does not appear to cause disease in humans and, accordingly, causes a weak immune response.
Adeno-associated virus can infectdividing and non-dividing cells and integrating their genome into the host genome. These features make AAV a particularly attractive candidate for creating viral vectors for gene therapy.
Then, the activation of the light-emitting diode device implanted in the chest allowsThe combination of the newly discovered antiarrhythmic effector effector function of the heart with the arrhythmia detector function of a closed-chest machine heart rate monitor in adult rats made it possible to automatically and rapidly detect and complete the arrhythmia in a safe, effective, repetitive manner, but without shock strokes.