Japanese scientists and cardiovascular experts analyzed the biochemical processes
Biologists have discovered that the compound succinyl-CoAdecreased significantly. It is an intermediary in the cellular cycle of tricarboxylic acids. In turn, this cycle inside mitochondria plays an important role in the breakdown of organic molecules with the release of energy.
Further studies showed that the decreaselevels of succinyl-CoA was at least partially caused by its excessive consumption of heme for synthesis. It is required for mitochondrial oxidative phosphorylation, which, in turn, is required for the transfer and synthesis of energy-carrying and storage molecules by mitochondria.
Hemes are complex compounds of porphyrins with ferrous iron, carrying one or two axial ligands. Hemes act as prosthetic groups of proteins - hemoproteins.
When scientists added 5-aminolevulinic acid(5-ALA) in the drinking water of mice immediately after the blood supply to a part of the heart was cut off, this significantly improved their cardiac function, treadmill performance, and survival. At the molecular level, the compound improved the ability of cardiac muscle mitochondria to undergo oxidative phosphorylation and appeared to restore their succinyl-CoA levels.
Mitochondria are small organellespresent in almost every cell and responsible for converting carbohydrates, fats and proteins into energy to provide biochemical reactions. Chronic heart failure is associated with mitochondrial dysfunction, but Little is known about how this happens at the molecular level.
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