The researchers explained that stem cells, due to their ability to replace damaged cells,
Majid Varkiani from Technological UniversitySidneya led a translational study in collaboration with industry partner Regeneus, an Australian biotechnology company developing stem cell therapy for inflammatory diseases and pain.
“Our cutting-edge technology, which uses3D printing and microfluidics to integrate multiple manufacturing steps into a single device will help make stem cell therapy cheap. While this world's first system is still in the prototype stage, we are working closely with biotech companies to commercialize the technology. It is important that this is a closed system without human intervention, which is necessary for modern Good Manufacturing Practice,” said Professor Varkiani.
To do this, they use microfluidics - this isprecise fluid control at the microscopic level that can be used to manipulate cells and particles. Advances in 3D printing have made it possible to directly create microfluidic equipment, which means rapid prototyping and integrated systems.
A new system has been developed to processmesenchymal stem cells that can divide and differentiate into various tissue cells, including bone, cartilage, muscle, fat and connective tissue.
Mesenchymal stem cells originallyextracted from human bone marrow, adipose tissue or blood. They are then transferred to a bioreactor in the laboratory and combined with microcarriers so that the cells can proliferate.
The new system combines four micromixers,spiral microfluidic separator and microfluidic concentrator for separation of mesenchymal stem cells from microcarriers and their concentration for further processing.
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