Ламы, верблюды и альпаки производят небольшие количества антител с более простой структурой, которые можно
Using advanced visualization techniques withX-rays and electrons at the Diamond Light Source (accelerator complex, third-generation synchrotron radiation source) at Oxford University, the team also determined that the nanobodies bind to the pointed protein in a completely new way. The difference was obvious when compared with other previously detected antibodies.
There is currently no treatment or vaccine forCOVID-19. However, it has been shown that transfusion of critically ill patients with serum from recovered people who contain human antibodies against the virus significantly improves the clinical outcome of the disease. This process, known as passive immunization, has been used for over 100 years, but it’s not easy to identify the right people with the right antibodies and to safely put such a “product” into the bloodstream. A laboratory product that can be made on demand will have significant benefits and can destroy the coronavirus.
New nanobodies have the potential toused similarly to convalescent serum, effectively stopping the progression of the virus in sick patients. Scientists were able to combine one of the nanobodies with human antibodies. The experiment showed that this combination was even more powerful than either component alone.
Scientists noted that three nanobodies can bind to peaks of the virus, essentially covering the parts that it uses to enter human cells.
The team is studying preliminary results,which show that the immune system of the laboratory llama produces antibodies that are different from those already identified, which will test the cocktails from nanobodies for viruses.
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