We found that we could organize objects, such as cells, in such a way that they could generate
Others have had to add magnetic particles to the cells to make them respond to the magnetic field, but this approach canInstead, we manipulated the magnetic nature of the environment that surroundscages, this allowed us to arrange objects with the help of magnets.Hannah Zlotnik, first author of the study and a PhD student in bioengineering at the McKay Orthopaedic Research Laboratory in Pennsylvania
In humans, tissues such as cartilage can often break down, causing joint instability or pain.Often, the collapse does not occur completely, but covers the area, forming a hole.
Treatment now suggests the holes are fillingsynthetic or biological materials that can work but often wear out because they are not the same materials as they used to be. This is similar to how potholes on the road are repaired: they are covered with gravel. In this case, the pit will be smoothed out, but over time such a structure wears out because it is not the same material and it cannot be glued in the same way.
A team of scientists found that when addingmagnetic fluid to a three-dimensional hydrogel solution, cells and other non-magnetic objects, including microcapsules for drug delivery, can organize certain patterns that mimic natural tissue by using an external magnetic field.
After brief contact with the magnetic field, the hydrogel solution (and the objects in it) were exposed to ultraviolet light in a process called "photocrosslinking" to lock everything in place.The magnetic solution was then dissipated, and the constructed tissues then maintained the required cell gradient.Using this magnetic modeling technique, the team was able to recreate articular cartilage.
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