It is impossible to predict in what form a person will suffer from COVID-19: severe or mild. Doctors still haven't
Researchers from Beth Israel Medical CenterDeaconess in Boston, under the leadership of Robert Gerszten, MD, head of the department of cardiovascular medicine at the center and professor at Harvard Medical School, decided to link the severe form of coronavirus and the structural features of genes.
Patients with COVID-19 show a wide range ofspectrum of clinical manifestations - from flu symptoms to acute respiratory infections. It is known that cardiovascular and metabolic diseases are risk factors, but it is not clear why some people have life-threatening disease and others do not.
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The authors examined the genomes of 4,856 patients fromCOVID-19 survivors from China, Europe and the United States found variations in the two regions that determine the severity of the disease. They then identified which proteins encode these regions of the genome and what role these proteins play in the body in the context of disease.
It turned out that one of the two regions of the genome wasassociated with the CD209 antigen. This is the protein with which the coronavirus enters and infects human cells. Another point was related to the poorly studied protein CXCL16, which scientists believe helps distribute immune cells to sites of infection.
The authors believe their work will help better understand how to deal with a new disease.
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