The biomarker adsorbed to graphene generates a force that deforms the graphene into a dome shape. So
Measuring device for simple and fastDisease examination is extremely important for accurate diagnosis, verification of therapeutic effects and investigation of recurrence and metastasis. If diseases can be studied using very small amounts of body fluids, such as blood or urine, physical conditions can be monitored simply, quickly and cheaply.
The methodology for determiningthe presence or absence of a disease by specifically capturing a biomarker on a flexibly deformable thin film formed using semiconductor microprocessing methods. The research team has developed a sensor technique to detect film deformation caused when a marker molecule is adsorbed as color changes. When the film thickness for biomarker adsorption decreases, the sensitivity of this sensing element can be increased.
Film deformation and change in interference color upon adsorption of a molecule on suspended graphene.
In a previous study in whichsuspended bridge graphene was used, however, changes during physical adsorption of the molecule into suspended graphene were measured, and it was difficult to specifically determine the molecule to be measured. As for the reason for this, it is believed that since modification using antibodies to recognize and specifically bind molecules is usually carried out in solution, the suspended structure of graphene was destroyed during treatment with the solution.
The research team thus createdtrampoline structure, in which the substrate irregularities were covered with a graphene sheet in the form of a suspended graphene structure that could resist solution treatment and was capable of modifying the graphene with an antibody molecule. The graphene surface was functionalized with an antibody molecule to provide the ability to recognize the molecule, and an ultrasensitive biosensor that can specifically detect the biomarker was obtained.
Light detection method unique toresearch group, was used as a method to detect a biomarker associated with the graphene surface. In a gap of less than 1 micrometer between suspended graphene and a semiconductor substrate, color changes depending on the length of the gap when exposed to light. Using this effect, the appearance of a molecule adsorbed on suspended graphene in the test solution was detected by a color change.
According to the biosensing technique developed this time, it is expected that sensitivity per unit area will be improved 2000 times compared to conventional sensors.
In addition to blood tests, researchthe group also investigated a chemical sensor for odor and chemical detection and believes that the sensor can be applied to a new compact sensor device that contributes to the IoT community. The sensor can be used to detect various biomarkers, as well as to detect viruses by changing probe molecules that modify the surface of graphene.