Bioengineers from the Houston Methodist Research Center have developed an implantable
The NDES device consists of a reservoir withstainless steel medicine containing nanochannels. This technology creates a membrane that provides stable diffusion when the drug is released. Scientists place the implant inside the tumor, which provides a gradual release in small doses of monoclonal antibodies-CD40 agonists, an antitumor immunotherapy agent.
During the study, scientists implantedNDES in laboratory mice with pancreatic cancer. The result was tumor reduction at a dosage four times lower than conventional treatment with systemic immunotherapy. In addition, the introduction of the implant into only one of the two tumors led to a decrease in both.
Adenocarcinoma of the pancreatic ductsone of the most aggressive and intractable types of cancer. It is often diagnosed in the late stages. In fact, about 85% of patients already have metastases at the time of diagnosis.
Immunotherapy holds promise as a cancer treatment for whichbefore there were no good options. But because conventional immunotherapy is administered throughout the body, it causes many side effects that sometimes persist for a long time, if not a lifetime. By focusing delivery directly on the tumor, it is possible to protect the body from toxic effects, the scientists note.
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Cover image: Houston Methodist