The new technique connects solid layers and is responsible for the formation of their three-dimensional structure.
For this they
The authors of the work seeded cells in polymer templates, which were in a nutrient medium that promotes the formation of the formation of various types of bone cells.
By changing environmental conditions, scientists began to observe how these shifts, including various mechanical loads, acted on stem cells.
As a result, scientists have identified two sets of signalsgrowth and the conditions under which stem cells turned predominantly into osteoblasts or osteocytes - the cells that make up bones. The former are responsible for the formation of bone tissue, while the latter combine into a kind of network and regulate the activity of osteoblasts.
So the author got a full-fledged fibrousbone tissue, indistinguishable from what it looks like inside a human embryo during the formation of its bones. They plan to continue to improve the development.
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