An unknown ability of hormones has been discovered. It will help treat skin diseases

Previously, researchers believed that neutrophils and monocytes (white blood cells) work in conjunction to

removal of bacteria from an infected area of ​​the skin. When these cells work together, they act as the body's first line of defense.

But this study showed that monocytes themselvesby themselves can promote faster healing of wounds. Monocytes aid the healing process by regulating leptin levels and blood vessel growth during wound healing. They also produce ghrelin, a hormone that helps wounds heal faster.

The hormone ghrelin is produced by the stomach when youhungry, and leptin is produced by fat cells after you have eaten and feel full. This balance between ghrelin and leptin has long been considered critical for metabolism and nutrition, but until now its relationship to immune mechanisms and tissue repair has not been known.

Using in vivo microscopy, which allows the observation of living cells, the scientists visualized the immune response to Staphylococcus aureus (S. aureus) bacteria in an animal model.

Staphylococcus aureus is a microbe thatare usually found on the skin or in the nose of a healthy person. It can be a catalyst for a wide range of diseases associated with skin and tissue infections, such as abscesses or boils. In some cases, the bacteria can lead to severe infections such as pneumonia and endocarditis, a life-threatening inflammation of the inner lining of the chambers and valves of the heart.

After infection with S.aureus, the body recruits these beneficial immune cells, neutrophils and monocytes. Neutrophils cleanse the body of bacteria, while monocytes help repair tissues. In the absence of monocytes, there is increased production of leptin, which leads to the growth of blood vessels during infection. The result can be delayed healing and scarring. Conversely, monocytes produce ghrelin at the site of infection, which blocks the formation of leptin-induced overgrowth of blood vessels, leading to tissue repair.

Lead investigator J. Paul Kubes and his research team believe this research will help introduce metabolic hormones (ghrelin and leptin) to the fields of immunology and microbiology.

“Despite the fact that the translation of our research intoWhile the practical plane will require many more experiments and employ a model more closely related to human disease, today we made a fundamental discovery that could improve tissue repair in humans, especially in hard-to-treat cases,” said Rachel Kratophil, co-author of the study.

Next, the researchers want to study in more detailfunction of immune cells such as neutrophils during infection. They are interested in how neutrophils are cleared of infection and whether they perform other functions in addition to clearing bacteria.

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