The bacterium that causes typhoid fever is rapidly becoming resistant to drugs, according to new research.
Today the only way to effectively treattyphoid fever - antibiotics. Namely, we are talking about the bacterium Salmonella enterica serovar Typhi (S Typhi). But over the past three decades, its resistance to oral antibiotics has only increased.
Researchers sequenced the genomes of 3,489 strainstyphoid fever that infected people from 2014 to 2019 in Nepal, Bangladesh, Pakistan and India. Researchers have found that the number of extensively drug resistant (XDR) bacteria is on the rise.
XDR typhoid is not only immune to antibioticsfirst-line antibiotics such as ampicillin, chloramphenicol and trimethoprim/sulfamethoxazole, but is becoming resistant to newer antibiotics such as fluoroquinolones and third-generation cephalosporins.
Today there is only one oral antibiotic left: the macrolide azithromycin. Researchers say its effectiveness won't last long either.
If left untreated, up to 20% of cases of typhoid fever can be fatal. Today there are 11 million cases of typhoid fever per year.
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