In order to find out this physical feature, biologists conducted a comparative genetic analysis
This was necessary to understand the featuresgenome SARS-CoV-2, in particular its replication pathogenicity and host vulnerability, as well as identify genome-wide patterns of variation in different SARS-CoV-2 strains that reflect selection effects.
Thus, biologists found that in the genomevirus, there are unique sequence signatures in the 3-UTR region that are involved in the interaction with the human microRNA hsa-miR1307-3p. Accordingly, the miR1307 molecule contains the key to how a person transmits coronavirus.
We conducted a systematic comparative analysisgenes by examining how and to what extent the SARS-CoV-2 genome sequence differs from other well-studied human and animal coronavirus genomes. The results of our research will allow us to develop models of interaction between the virus and its hosts, improving our understanding of the mechanisms that cause SARS-CoV-2 disease and how to use therapeutic targets for treatment.
Nicholas Schork, professor and director of the Department of Quantitative Medicine and Systems Biology at TGen.
As a result, scientists believe that the miR1307 geneit can sort of switch different genes of the virus: it can make the disease more or less severe for the body. For example, it regulates the replication rate of the virus.
The authors hope that their discovery will servekey for the development of a new type of COVID-19 vaccine based on proteins or RNA, as well as specific genetic markers to monitor the spread of the disease and track the transmission of the virus from one species to another.
Earlier, Hi-Tech wrote about another antigen, CD209. Scientists have found that this is the protein with which the coronavirus penetrates and infects human cells.
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