Scientists have created a bank of organoids — tiny three-dimensional structures that are grown from stem cells —
To learn more about organ host factors,which are especially important for the replication and spread of coronaviruses, scientists have created a biobank of mutant intestinal organelles. This means that organelles that mimic the biology of the human gut contain various mutations in host factors, such as are relevant to coronaviruses. According to scientists, it is mutations that cause changes in the activity of host factors.
Credit: Joop Beumer, Hubrecht Institute.
For example, scientists have observed how SARS-CoV-2 (red in the photo above) effectively infectsAt the same time, organelles deficient in TMPRSS2 (membrane-bound serine protease, productgenes TMPRSS2) are not damaged by the virus.
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