Bunyaviruses (Bunyaviridae) are mainly transmitted by insects, such as mosquitoes, and have a devastating effect on
"Antiviral therapy and therapy withUsing antibodies is considered the most effective means of combating emerging infections, explains co-author of the study, Paul Wichgers Schreur, a senior fellow at Wageningen Bioveterinary Research. - Specific antibodies, also known as VHH, have shown great potential to neutralize the respiratory tract virus of infants. We investigated whether the same antibodies can be effective against bunyaviruses. "
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VHH is a type of antibody that can bindfragments of other chain antibodies. They were discovered 25 years ago and have since been used in clinical therapy and immunodiagnostics, and more recently, for environmental monitoring.
When researchers tested whether VHH couldneutralize different viruses in vitro, they found they couldn't do it alone. The combination of two VHHs had a greater neutralizing effect against Schmallenberg virus (SBV), but was ineffective against Rift Valley fever (RVFV). To solve this problem, they used “superglue” to hold the VHH together and use it as a single antibody complex. It effectively neutralizes both viruses.