Scientists have presented a new strategy for the treatment of lung cancer. The payload is released directly
Using a new method, the doctor injects nanoparticlesintravenously, and then exposes the tumor to an alternating radio frequency magnetic field (AMF-RF) from the outside. As a result, the nanoparticles will warm up slightly and release the therapeutic payload exactly where it is needed.
The payload in question isis a short strand of RNA known as miRNA. In this case, the researchers coupled the nanoparticles with a synthetic version of miRNA called miR-148b. Previous experiments have shown that it is able to suppress the growth of tumors. Using a heat-sensitive chemical bond (the Diels-Alder reaction), they connected the particles and miRNAs. When heated using AMF-RF, it decomposed and released microRNA.
After testing nanoparticles in cancer cellslungs, it turned out that the particles successfully penetrate the cells and release the microRNA payload when exposed to AMF-RF. A day later, the researchers ran tests to see if the treated cancer cells had died. The experiment showed that most of them really died.
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