Coronavirus Evolves To Be Immune To Current Vaccines And Antibodies

The study of new coronavirus variants was published in the journal Nature on March 8, 2021, following a preprint in

January.Scientists' predictions are confirmed by the first results of the Novavax vaccine. The company said on January 28 that the vaccine was nearly 90% effective in trials in the UK, but only 49.4% effective in South Africa. There, most COVID-19 cases are caused by the B.1.351 coronavirus variant.

“Our research and new data from clinicaltests show that the virus is 'eluding' our current vaccines and treatments, "said David Ho, MD, director of Aaron Diamond Research Center. pursuit of the developing SARS-CoV-2 ”.

After vaccination, the immune system responds and produces antibodies that can neutralize the virus.

Scientists have discovered that antibodies in blood samplestaken from people vaccinated with the Moderna or Pfizer vaccine were less effective at neutralizing two variants: B.1.1.7, which emerged last September in England, and B.1.351, which emerged in South Africa in late 2020. According to the British version, neutralization decreased by approximately 2 times, and according to the South African version - by 6.5-8.5 times.

The new study did not study the more recentvariant found in Brazil (B.1.1.28) But given the similar spike mutations between the Brazil and South African variants, Ho says that the Brazil variant should behave similarly to the South African variant.

We must stop the replication of the virus, and thismeans faster deployment of the vaccine, wearing masks and maintaining social distancing. Stopping the spread of the virus will also stop the development of further mutations.

David Ho, MD, Director of Aaron Diamond Research Center

The study also found that somemonoclonal antibodies currently used to treat COVID-19 patients may not work against the South African variant. And based on the results with plasma from patients who were previously infected during the pandemic, variant B.1.351 from South Africa could cause reinfection.

Let us remember that monoclonal antibodies areantibodies developed in the laboratory and administered to patients as part of specialized therapy. These antibodies (also called immunoglobulins) trigger a targeted response in the body to protect it from attack by foreign antigens.

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