Developed sensitive biosensor for early detection of cancer

Researchers from the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences

created a nanosurface sensitive to exosomes. These are microscopic extracellular vesicles (vesicles) with a diameter of 30 to 150 nm, originating from tumor cells.

Scientists used nanosheets for their sensorMXene, a two-dimensional material with high surface area, high electrical conductivity and catalytic abilities. The researchers cover the two-dimensional material with gold nanostructures.

Diagnosis based on markers of two proteins increases the sensitivity of the sensor. Image: Qiannan You et al., Biosensors and Bioelectronics

The composite membrane is additionally enrichedaptameramime sensitive to EpCAM and CD63 proteins. Recall that aptamers are oligonucleotide or peptide molecules that specifically bind to specific substances. EpCAM is a cell adhesion molecule that is expressed only in epithelial cells and tumor tissues, while CD63 is a membrane protein characteristic of the early stages of cancer development.

The study showed that the new sensordemonstrates high accuracy and sensitivity in the diagnosis of cancer based on liquid biopsy (blood and other liquid media). The device achieved high sensitivity and reliable performance for detecting exosomes with a low detection limit (58 particles/µl) in a linear range from 1×102 to 1×107 particles/µl.

Read more:

Plant on Mars produces oxygen at the rate of an average tree

Physicists have cooled atoms to record temperatures. They are a billion times colder than outer space.

A small dinosaur "turned" into a gem. He is almost 100 million years old