Researchers from the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences
Scientists used nanosheets for their sensorMXene, a two-dimensional material with high surface area, high electrical conductivity and catalytic abilities. The researchers cover the two-dimensional material with gold nanostructures.
Diagnosis based on markers of two proteins increases the sensitivity of the sensor. Image: Qiannan You et al., Biosensors and Bioelectronics
The composite membrane is additionally enrichedaptameramime sensitive to EpCAM and CD63 proteins. Recall that aptamers are oligonucleotide or peptide molecules that specifically bind to specific substances. EpCAM is a cell adhesion molecule that is expressed only in epithelial cells and tumor tissues, while CD63 is a membrane protein characteristic of the early stages of cancer development.
The study showed that the new sensordemonstrates high accuracy and sensitivity in the diagnosis of cancer based on liquid biopsy (blood and other liquid media). The device achieved high sensitivity and reliable performance for detecting exosomes with a low detection limit (58 particles/µl) in a linear range from 1×102 to 1×107 particles/µl.
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