Changes in diet and lifestyle have led to an increase in the incidence of asthma, allergies, problems in
Scientists believe that microbiota collected from a healthy person at a young age will help “rejuvenate” the digestive system and cope with various diseases.
The proposed scheme of the bank.A young and healthy person undergoes an examination and submits stool samples to the bank. When a disease is found that can be cured by a fecal transplant, the microbiota is restored, transferred to the hospital where the transplant is performed. Image: Shanlin Ke et al., Trends in Molecular Medicine
Fecal microbiota transplantation istransplantation of intestinal bacteria and bacteriophages contained in the feces of a healthy person or several healthy people to a patient. The use of donor feces has already shown its effectiveness, for example, in the treatment of infections caused by Clostridioides difficile and in the fight against obesity, the authors note. In addition, preliminary animal studies have shown the effectiveness of stool transplants for rejuvenation.
But this method of treatment is limited due to genetic differences between the donor and the recipient. The authors of the work believe that their own feces will help solve this problem.
Conceptually the idea of storing a chair forautologous faecal microbiota transplantation is similar to when parents save their child's umbilical cord blood for possible future use. There is more potential for storage of stool samples and we expect that stored feces are much more likely to be used than cord blood.
Yang-Yu Liu, associate professor at Harvard University and co-author of the publication
The authors of the work note that the key problem inToday is the lack of developed technologies for long-term safe storage and subsequent resuscitation of stool samples. Further research is needed on cryopreservation, recovery and culture of preserved feces.
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