Dutch doctors have taught the heart using bioelectronic system to remove an attack of arrhythmia

Existing therapeutic methods for restoring sinus rhythm in symptomatic fibrillation

atrial fibrillation ("atrial fibrillation" – "Hi-tech") require hospitalization of the patient, as they includeHigh-voltage shock therapy, which completely excludes outpatient treatment, but continuous, and most importantly, rapid restoration of sinus rhythm is extremely necessary for the patient, since atrial fibrillation hasResearchers from the Laboratory of Experimental Cardiology have developed a hybrid bioelectronic system for shock-free termination of fibrillation, which allowsThe heart acts as an electrical current generator for the autogenous restoration of sinus rhythm.

Local delivery to the right atrium of adeno-associated viral vectors  encoding a light-guided depolarization ion channel leads toto efficient and spatially limited transgene expression.

Adeno-associated virusis a small virus that infects human cells and some other primates.It does not appear to cause disease in humans and, accordingly, causes a weak immune response.

Adeno-associated virus can infectdividing and non-dividing cells and integrating their genome into the host genome. These features make AAV a particularly attractive candidate for creating viral vectors for gene therapy.

Then, the activation of the light-emitting diode device implanted in the chest allowsThe combination  of the newly discovered antiarrhythmic effector effector function of the heart with the arrhythmia detector function of a closed-chest machine heart rate monitor in adult rats made it possible to automatically and rapidly detect and complete the arrhythmia in a safe, effective, repetitive manner, but without shock strokes.