Existing therapeutic methods for restoring sinus rhythm with symptomatic fibrillation
Local delivery to the right atriumadeno-associated viral vectors encoding the ion channel depolarization with light control, leads to efficient and spatially limited transgene expression.
Adeno-associated virus - A small virus that infects human cells and some other primates. Apparently, does not cause disease in humans and, accordingly, causes a weak immune response.
Adeno-associated virus can infectdividing and non-dividing cells and integrating their genome into the host genome. These features make AAV a particularly attractive candidate for creating viral vectors for gene therapy.
Then the activation of the implanted in the thoracicA cell of a light-emitting diode device allows you to stop atrial fibrillation, effectively illuminating part of the atrium. The combination of the newly discovered antiarrhythmic effector function of the heart with the function of the arrhythmia detector of the heart rate monitor in the closed chest of adult rats allowed us to automatically and quickly detect and complete the arrhythmia in a safe, effective, repetitive mode, but without shock strokes.