Existing therapeutic methods for restoring sinus rhythm with symptomatic fibrillation
atrial flutter ("flickering arrhythmia" - "High tech")require hospitalization of the patient, as they include high-voltage shock therapy, completely excluding outpatient treatment. But continuous, and most importantly, rapid recovery of sinus rhythm is extremely necessary for the patient, since atrial fibrillation is repetitive and progressive. Researchers from the Laboratory of Experimental Cardiology have developed a hybrid bioelectronic system for the unaccented cessation of fibrillation, which allows the heart to act as an electric current generator for autogenous recovery of sinus rhythm.
Local delivery to the right atriumadeno-associated viral vectors encoding the ion channel depolarization with light control, leads to efficient and spatially limited transgene expression.
Adeno-associated virus - A small virus that infects human cells and some other primates. Apparently, does not cause disease in humans and, accordingly, causes a weak immune response.
Adeno-associated virus can infectdividing and non-dividing cells and integrating their genome into the host genome. These features make AAV a particularly attractive candidate for creating viral vectors for gene therapy.
Then the activation of the implanted in the thoracicA cell of a light-emitting diode device allows you to stop atrial fibrillation, effectively illuminating part of the atrium. The combination of the newly discovered antiarrhythmic effector function of the heart with the function of the arrhythmia detector of the heart rate monitor in the closed chest of adult rats allowed us to automatically and quickly detect and complete the arrhythmia in a safe, effective, repetitive mode, but without shock strokes.
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