E. coli is usually found in the intestines, where it causes no harm, but if it enters the bloodstream
Antibiotic resistance of E. colihas grown steadily since the early 2000s, despite attempts to control it. In the largest genomic study of E. coli to date, which has taken more than 16 years, researchers have successfully tracked the spread of antibiotic-resistant genes and have shown that these genes are passed between strains of E. coli.
In the process, the authors found that resistant strains developed around the same time, but increased more rapidly in the UK population.
The results of the work show thattracking these resistant strains is important for surveillance and control of drug-resistant E. coli, where it can cause severe infection and mortality. In addition, understanding how these genes are transferred between strains and what led to their acquisition of drug resistance may help prevent the rise of antibiotic-resistant strains.
Multiple drug resistance (MDR)relatively rare in bacteria. However, this new study found that lines that had not previously been associated with MDR acquired drug resistance genes, demonstrating an increased ability of E. coli to share MDR genes that move horizontally between strains.
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