Engineers have developed a miniature encephalograph for the “brain in a test tube”

A team of researchers led by Johns Hopkins University adapted the system

electroencephalography for researchorganoids that mimic the functioning of the brain. The new device resembles the classic “cap with electrodes” used to search for brain tumors. It will help in the study of nervous disorders and the effects of various substances on brain function.

In their work, scientists usedself-folding polymer sheets with conductive polymer coated metal electrodes. Tiny microcapsules cover the entire spherical shape of the organoid and provide 3D recording from the entire surface.


Brain organoids in a Petri dish (left) and an EEG device (right). Image: Qi Huang, Gayatri Pahapale, Gracias lab, Johns Hopkins University

Organelles are complex miniature models,grown from stem cells are used to study organ development. In the decades since the advent of the technology, scientists have been able to create tiny models of the kidneys, lungs, heart, and other organs in the lab. A mini-brain organoid is a lab-grown ball of stem cells that mimics some of the structures and functions of the brain.

Organoids, especially mini-brains, gain everythinggreater value in medical research because they can be used in experiments that would otherwise require testing on humans or animals. 

Creating electrodes for the device. Image: Qi Huang et al., Science Advances

The disadvantage of the previously used technologies is thatthat the sensors only recorded data in one plane. A new three-dimensional EEG will help scientists better understand what processes various chemicals cause in organelles. This will help develop new safe drugs.

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