First independent study of Sputnik V: it is 81% efficient. How did you find out?

According to the researchers, this is the first work in which it was possible to study the effectiveness of the vaccine in Russia in

real conditions.The authors observed in real time which patients were sent for outpatient treatment and which were hospitalized. In addition, according to the results of the work, it turned out that Sputnik V is approximately as effective in dealing with the delta strain as Pfizer, Moderna and AstraZeneca.

What is known about the research results?

To study the effectiveness of the vaccine,The researchers used data on 13.8 thousand patients, among them 1.2 thousand people received two components of the Sputnik V vaccine. Of those fully vaccinated, almost all were sent home for outpatient treatment and only 17 people had to be hospitalized—that’s 3.4% of all vaccinated people.

Also, the effectiveness varied depending on gender: for women it was 84%, and for men - 76%; as well as on age: for people over 50 years old - 82%, and in the group of 18–49 years old only 63%.

We have seen a sharp rise in the likelihoodhospitalizations as age increases for unvaccinated patients, compared with almost the same relationship between age and hospitalization probability for the fully vaccinated group of patients.

Research text

How did the study go?

During their work, scientists used informationtwo outpatient centers of the Sergey Berezin Medical Institute (MIBS), where patients were admitted. As Mikhail Cherkashin, Deputy Chief Physician for Medical Affairs at MIBS, explained, these medical institutions accept patients with signs of SARS-CoV-2 and positive test results. Next, employees decide whether to hospitalize the person or send him for outpatient treatment.

According to Cherkashin, during mass vaccinationin July 2021, MBIS staff and representatives of the European University had the idea to study the question of how effective the vaccine is in real life. He concluded that people vaccinated with two doses suffer only from mild symptoms of the disease - a severe form was not detected during work.

Is this really the first independent study? And before that, there was not a single similar one?

Yes, independent research "Sputnik V" beforewere not carried out. Among the scientific works was the research Center. Gamaleya, it said that the vaccine could protect the body from new variants of SARS-CoV-2.

Even earlier, the international medical journal TheThe Lancet published the results of the third phase of trials: they were provided by the creators of the Sputnik V vaccine. Then 20 thousand people participated in the study. The conclusion stated that both components are safe for human health and cause an immune response.

Also on June 25, the Argentine Ministry of Health publishedthe report on the side effects of the Russian vaccine, on all vaccinated such cases were less than 1%, according to researchers, and mortality decreased by 70-80% among patients over 60 years old.

So in the end, does the vaccine do well with the delta strain?

In an independent study, scientists found thatthat Sputnik V copes with the delta variant in 81% of cases. But these data cannot be correlated in any way with clinical studies, which say that the vaccine is 91.6% effective. These two studies cannot be compared and an average effectiveness cannot be derived.

If the first work examined how much the vaccinehelps against hospitalization, then during the second question the question was completely different - how often vaccinated people suffer from SARS-CoV-2 compared to those who were given a placebo.

Are other vaccines as effective against delta or not?

Yes, the level of efficiency is roughly the same.If we talk about Moderna, Pfizer and AstraZeneca together, then their overall efficiency compared with the alpha option decreased from 89% to 79%, but hospital admissions remained at the same level - 96%.

If we talk only about the level of hospitalization, then, according to vaccination data in Qatar, Pfizer protects against severe consequences by 97.3%, and among those vaccinated with Moderna there was not a single hospitalization.

Also, according to the results of the Mayo Clinic,the risk of hospitalization was reduced compared with those who were not vaccinated by 81% (33–96.3%) for those vaccinated with Moderna and by 75% (24–93.9%) for those who received the full course of Pfizer.

Published research is important because itmay increase citizens' loyalty to the Sputnik V vaccine: it contains information about the effectiveness of the vaccine against the world's dominant strain, delta.

More evidence has emerged in favor ofthat vaccines, although they lose their effectiveness due to mutations, are not so fast. Therefore, the Sputnik V vaccination is a good way to protect yourself from severe consequences when infected with SARS-CoV-2.

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