Previously, scientists learned that microglia, or auxiliary brain cells, can capture and destroy
In order to understand the reasons for the development of thesefailures and methods of restoring the functioning of microglial cells, the authors compared the vital activity of microglial cells in the brain of healthy mice and a special breed of rodents genetically predisposed to the development of the most aggressive forms of Alzheimer's disease.
It turned out that the HIF1A gene and relatedDNA regions had increased activity in microglial cells of rodents with Alzheimer's disease. The authors also found similar disruptions in the work of this part of the genome in cell cultures extracted from the brains of people with advanced forms of Alzheimer's.
Until we can say exactly how it relatesthe level of activity of this gene with how quickly the disease progresses. We plan to use the CRISPR genomic editor to observe how increasing or decreasing HIF1A activity will affect the rate of development of Alzheimer's disease.
Gabriel Chu, Research Fellow at Duke University (USA)
So far, the authors of the work cannot say exactly how the discovered gene affects the development of the disease.
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