A molecule has been found that reduces hunger. It is easy to “launch” in the body

Biologists have found a modified amino acid that increases sharply in the blood after intense exercise.

exercise and travels to the brain to suppress hunger and, in turn, lead to weight loss.

“We all know that exerciseuseful,” said Jonathan Long, an assistant professor of pathology at Stanford University who led the study. “For example, to control body weight and glucose levels. But we wanted to look at this concept in more detail, namely, whether we could analyze exercise in terms of molecular pathways.”

To do this, scientists used metabolomicsand a mass spectrometry technique to track the concentrations of various molecules in tissue and blood samples, as well as how exercise causes levels of certain molecules to rise and fall. Let us remember that metabolomics helps to find unique chemical “fingerprints” specific to processes occurring in living cells.

Scientists conducted an experiment on mice,and then on horses and forced them to perform physical exercises. They found a mysterious molecule that was active after exercise. It “went to the brain,” scientists write, and suppressed the feeling of hunger. It turned out that it is a hybrid of two naturally occurring chemical compounds: lactate and phenylalanine.

Lactate causes a burning sensation when wewe strain our muscles to the point of exhaustion, and phenylalanine is an amino acid that acts as a building material for proteins. Together they form a molecule scientists call lac-phe. It, as further studies showed, is catalyzed by the protein CNDP2, which is very active in immune cells. Mice that lacked this protein were unable to produce lac-phe, so they ate more and gained more weight than controls with normal CNDP2 activity.

In a new experiment, scientists introducedlac-phe molecule in a group of obese mice. This reduced their food intake by about 30%, which in turn reduced their body weight and fat and improved glucose tolerance, which helps prevent diabetes.

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