Biologists have found a modified amino acid that rises sharply in the blood after intense
We all know that exerciseuseful,” said Jonathan Long, assistant professor of pathology at Stanford University, who led the study. - For example, to control body weight and glucose levels. But we wanted to look at this concept in more detail, namely, whether we can analyze the exercises in terms of molecular pathways.”
To do this, scientists used metabolomics anda mass spectrometry method for monitoring the concentration of various molecules in tissue and blood samples, and how exercise causes the levels of certain molecules to rise and fall. Recall that metabolomics helps to find unique chemical "fingerprints" specific to the processes occurring in living cells.
Scientists conducted an experiment on mice, and then onhorses and forced them to exercise. They found a mysterious molecule that was active after exercise. She "went to the brain," the scientists write, and suppressed the feeling of hunger. It turned out to be a hybrid of two naturally occurring chemical compounds: lactate and phenylalanine.
Lactate causes a burning sensation when wewe strain our muscles to the point of exhaustion, and phenylalanine is an amino acid that acts as a building block for proteins. Together they form a molecule that scientists call lac-phe. It, as shown by further studies, is catalyzed by the CNDP2 protein, which is very active in immune cells. Mice lacking this protein could not produce lac-phe, so they ate more and gained more weight than the control group with normal CNDP2 activity.
In a new experiment, scientists injectedlac-phe molecule in a group of obese mice. This reduced their food intake by about 30%, which in turn reduced their body weight and fat and improved their glucose tolerance, which helps prevent diabetes.
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