Scientists have discovered a previously unknown link that allows fat cells to directly "talk" to
The team visualized hidden sensory nervespaths using special equipment. She made animal tissues transparent. When the researchers broke the link, the mice burned more fat. Ultimately, the researchers concluded that disrupting this communication network could one day help treat obesity. In any case, if the results of the experiment are reproduced in humans.
Researchers used to know that the brain usesthe sympathetic nervous system to force the body to burn more fat. This branch of the nervous system “directs” the fight-or-flight response and uses fat as the body’s primary source of fuel. In other words, the researchers already knew how the brain uses neurons to send one-way information to fat tissue.
A new study finds that fat alsosends messages to the brain through sensory nerve cells or neurons known as dorsal root ganglia (DRG). They receive sensory information from the body to send signals to the brain through the spinal cord.
In a new study, researchers found thatDRGs transmit information not only from the skin to the brain, but also from adipose tissue. But it was not possible to understand what kind of information neurons transmit information - all because of the difficulty of visualizing neurons at large distances. The researchers solved this and other problems.
In this study, scientists fluorescently labeledDRG neurons that infiltrate adipose tissue. Using a system that renders animal tissue transparent, they saw DRG pathways from their origin near the spinal cord to brown fat.
Brown adipose tissue is one of two types of fattissues in mammals. It is well developed in newborns and in hibernating animals. In adults, brown adipose tissue is present and metabolically active, but it regresses with age.
When researchers used the virus toby destroying DRG neurons that are associated with brown fat, the mice burned more fat. The genes associated with fat production and heat production have increased. In addition, the mice did not gain weight after their DRGs were destroyed.
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Cover photo: Berkshire Community College Bioscience Image Library