Found a way to "reprogram" the heart after a heart attack

When a person has a heart attack, a large amount of scar tissue remains in his blood vessels,

which impedes the flexibility of the organ and,hence its functions. Researchers have studied how young hearts repair themselves and have found a way to transmute scar tissue into healthy tissue in mice, thereby reversing some of the damage caused by heart attacks.

Scientists from Duke University (DU) studiedfibroblast function. These cells are involved in the formation of both connective and scar tissue. But it turned out that adult fibroblast cells are resistant to reprogramming, in contrast to juvenile ones.

It turned out that the difference wasin the protein oxygen sensor Epas1, which did not allow adult cells to follow reprogramming instructions. When Epas1 was inhibited in adult cells, they successfully transformed.

With inhibited Epas1 researchThe team sent packets of RNA to mice that were having heart attacks. The RNA contained reprogramming instructions to turn fibroblasts into healthy heart tissue and was wrapped in exosomes, sac-like structures found throughout the body.

The technique turned out to be successful.“We were able to restore almost all cardiac function that was lost after a heart attack by reversing the aging of fibroblasts in the heart,” the scientists conclude. The study was published in the Journal of Biological Chemistry.

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