Found “cleaning protein” that saves the brain after a hemorrhage

We are talking about a protein known as cerebral dopamine neurotrophic factor.

neurotrophic factor, CDNF).It is now being actively studied to see if it will be useful in the treatment of Parkinson's disease. However, the authors of the new study found that it also boosts the response of immune cells after a brain bleed, working as a “cleaner.”

“It’s interesting that after a cerebral hemorrhagea lot of waste and “garbage” accumulates. To restore it, all this must be properly removed!” explains Vasilios Stratoulias, co-author of the study from the University of Helsinki. The scientists' findings were published in Nature.

Study Shows CDNF Accelerateshealing of hemorrhagic lesions, reduces cerebral edema and improves functional outcomes in the animal models used in the study. CDNF also alleviated cellular stress in the area surrounding the hematoma and helped immune cells find and remove accumulated waste.

"Surprisingly, cerebral dopamineNeurotrophic factor acts on immune cells in the bleeding brain, increasing anti-inflammatory mediators and suppressing the production of pro-inflammatory cytokines, which are responsible for cell signaling, emphasizes co-author Mikko Airavaara, a professor at the University of Helsinki. “This is an important step towards treating injuries caused by cerebral hemorrhage. There is currently no cure for this pathology.”

Intracerebral hemorrhage is local bleeding from blood vessels into the brain parenchyma. The most common cause of hemorrhage is arterial hypertension.

Research shows that only a quarterDeterioration of the brain condition associated with intracerebral hemorrhage occurs in the first 24 hours. Most problems are observed in the secondary stage, when blood cells are lysed and neurotoxic products are formed. Without effective treatment, this phase becomes increasingly deadly.

Read more:

The secret of longevity is revealed: scientists have figured out how to start the necessary mechanism in the human body

Named a new cause of autism

2,700-year-old temple found in Sudan He surprised scientists

Cover photo: www.scientificanimations.com, CC BY-SA 4.0, via Wikimedia Commons