A team of researchers from the University of Bristol showed that a mutation in the BPIFB4 gene, which is often
In different regions around the world meet the areago "blue zones", in which people live especially long, living up to 100 years or more. An analysis of the DNA of such centenarians showed that age record holders from different countries are united by genetic mutations. One of them is BPIFB4, a gene that scientists believe is linked to longevity.
In a new genetics study from BristolUniversity found that a single dose of BPIFB4 stopped aging (age-related changes and deterioration in function) of the heart in middle-aged mice. And when the gene was introduced into older mice, whose hearts show the same changes as in humans, the gene “rewound” the biological clock of the heart by more than ten years in terms of the age of mice to human.
In addition to experiments on mice, researcherstested the effect of the gene on human heart cells in vitro (in vitro). BPIFB4 was introduced into the heart cells of elderly patients with severe heart disease, and then compared the state and function of such modified cells compared with a healthy population.
The researchers found that when the gene was addedor a protein associated with it led to the rejuvenation of heart cells. Scientists studied the work of pericytes - connective tissue cells that are part of the walls of blood vessels. The study showed that the ability to build new blood vessels, partially lost by such cells in heart failure, is restored after an injection.
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