Biologists from the University of California, San Diego, have developed a material to treat the consequences
After a heart attack, damaged musclethe heart tissue is replaced by scar tissue that cannot contract, reduces muscle function, and leads to congestive heart failure. Previously, biologists at the University of California San Diego developed a hydrogel from the natural scaffold of heart muscle tissue. When injected into the damaged tissue of the heart muscle through a catheter, such material forms a scaffold in the damaged areas of the heart, stimulating the growth and restoration of new cells.
Now biologists have modified the hydrogel toavoid dangerous effects on the heart immediately after an attack. The new version of the gel can be given by intravenous injection. This avoids a dangerous effect directly on the weakened heart after an attack. To create a new gel, scientists passed the original version through a centrifuge, which made it possible to weed out larger particles and leave only nano-sized particles. The finished material was subjected to dialysis and sterile filtration, and then freeze-drying.
Rodent testing has shown thatthe biomaterial binds to endothelial cells inside the vessels, closing the gaps, accelerating healing and, as a result, reducing inflammation. Researchers on a model of a heart attack in a pig gave similar results.
The researchers requested permission to conductHuman clinical trials are estimated to begin within one or two years. In addition, the authors of the hydrogel plan to test its effectiveness for the treatment of traumatic brain injury and pulmonary arterial hypertension.
Read more:
Sword thought to be fake turns out to be a 3,000-year-old Bronze Age artifact
New passages from the Book of the Dead found in Egypt
Watch the hydrogen superyacht 'fly' over the water at 75 knots