Intestinal bacteria found to destroy brain cells

This is an IAA metabolite produced by the Ruminococcaceae family of intestinal bacteria. It affects the death of nerve

cells, leading to cognitive decline.

The team decided to conduct an experiment tounderstand how this metabolite affects brain function. The authors took old mice and found that with age, the number of Ruminococcaceae bacteria and the IAA metabolite in the body increases.

The metabolite itself binds to the promoter region of the S100A8 gene, then the gene is expressed, and then the formation of apoptotic bodies and the death of nerve cells.

To find out the consequences of getting IAA into the brain, the authors of the work orally injected a preparation containing this metabolite into young healthy mice and observed the reaction.

As a result of several behavioral andIn cognitive tests, it turned out that exposure to IAA led to a loss of cognitive function: rodents began to learn to navigate the maze and recognize objects worse. The opposite effect was observed when the scientists blocked the action of IAAs on microglia in older mice, resulting in improved memory and spatial learning.

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