Invisibility cloak helps bacteria attack cancerous tumors

Scientists have developed a chemical "invisibility cloak" that helps artificial bacteria penetrate

immune defense of the body.As a result, biologists have a unique and powerful system for delivering anticancer drugs. The system has already been tested on mice: it reduced tumors in mice. Scientists hope that this approach will solve the problems of toxicity of anti-cancer therapy.

In addition to traditional forms of cancer treatment - radiationtherapy, chemotherapy and immunotherapy, scientists use therapeutic bacteria to fight tumors. By themselves they can have a strong antitumor effect. Using genetic engineering, they can be improved. 

When bacteria are used, manyproblems, the main of which is the problem of toxicity. Live bacteria can multiply rapidly in the body, and because the body's immune system perceives them as a threat, this treatment can cause a strong inflammatory response.

In the new study, scientists used capsular polysaccharides (CAP), which naturally coat the surfaces of bacteria and protect them from immune attacks.

They ended up developing a version of bacteria thatwhich have a small IPTG molecule. It changes the surface at the right moment and affects how bacteria interact with the immune system. Essentially, this creates a molecular "invisibility cloak" that encapsulates bacteria and prevents immune attacks. Also, by adjusting the number of IPTG molecules, you can control how long the bacteria will live in the blood.

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