Staff at Columbia University, Cambridge and UC San Francisco
Previously, scientists experimented by transfusing bloodyoung mice to older mice, and found that this improves cognitive performance, increases lifespan, and delays age-related diseases in the latter. However, this is a temporary measure, and the authors of the new study were looking for a solution that rejuvenates the entire blood production system.
Scientists investigated the inflammatory signal of IL-1B inbody. It turned out that he is "responsible" for damage to blood stem cells. It has previously been associated with other inflammatory conditions, such as rheumatoid arthritis. So the researchers tested an already existing drug for the disease, anakinra, to block IL-1B in older mice.
Anakinra - immunosuppressant, inhibitorinterleukin. It is a recombinant version of the human interleukin-1 (IL-1ra) receptor antagonist produced by an E. coli strain using recombinant DNA technology.
Animal experiment has shown that stemblood cells returned to a younger and healthier state. It promoted the functioning and regeneration of blood cells. The treatment worked even better when the mice were given the drug throughout their lives, not just at the aging stage.
The scientists emphasize that the results of animal testing do not always apply to humans.
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