Staff from Columbia University, Cambridge University and the University of California at San Francisco
Previously, scientists experimented with blood transfusionsyoung mice to older mice, and found that this improves cognitive abilities, increases life expectancy and delays age-related diseases of the latter. However, this is a temporary measure, and the authors of the new study were looking for a solution that rejuvenates the entire blood production system.
Scientists investigated the inflammatory signal of IL-1Bin organism. It turned out that it is “responsible” for damage to blood stem cells. It has previously been linked to other inflammatory conditions, such as rheumatoid arthritis. So the researchers tested an existing drug for the disease, anakinra, to block IL-1B in older mice.
Anakinra is an immunosuppressant, inhibitorinterleukin. It is a recombinant version of the human interleukin-1 receptor antagonist (IL-1ra) produced by an E. coli strain using recombinant DNA technology.
An experiment on animals showed thatblood stem cells returned to a younger and healthier state. This contributed to the functioning and regeneration of blood cells. The treatment worked even better when the drug was administered to mice throughout their lives, and not just during aging.
Scientists emphasize that the results of tests on animals do not always apply to people.
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