Photothermal carbon dots can specifically bind bacteria and quickly heat up when exposed to
The use of antibiotics helps fightbacterial infection, but drug abuse has led to the emergence and widespread distribution of superbugs. As a result, the treatment of infectious diseases has again become a global problem.
To solve the problem, scientists usedphotodynamic therapy (PDT). This is a method of treating cancer, certain skin diseases or infectious diseases, based on the use of photosensitive substances - photosensitizers - and light of a certain wavelength.
Recently, technology has become widespreadspread in the treatment of bacterial infections. Recently, researchers from the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences developed bacteria-affinitive photothermal carbon dots (BAPTCD, bacteria-affinitive photothermal carbon dots) from o-phenylenediamine and D-glutamine acid (D-Glu) using the solvothermal method.
Through experiments, they discovered that BAPTCDs can specifically bind to bacteria and quickly heat up when exposed to laser light, destroying microbial cell walls and killing them.
It is noteworthy that for the synthesis scientistsused an intermediate with D-Glu. It exists only in prokaryotes, and only they can use D-type amino acids. Its D-Glu derivatives are often used to develop antibacterial agents to kill bacteria by inhibiting cell wall synthesis.
The experimental results showed that 80.33% of Escherichia coli and 89.27% of Staphylococcus aureus were killed by BAPTCD. In the future, this method could replace antibiotics.
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