Leukocytes turned into microrobots with the help of light

Medicinal microrobots could help doctors better treat and prevent diseases. But most

such devices are made from syntheticmaterials that cause immune reactions. Now researchers have used lasers to precisely manipulate neutrophils, a type of white blood cell, as a natural, biocompatible microrobot in living fish.

The researchers manipulated neutrophils,using focused laser beams as remote optical tweezers. The light-controlled microrobot could move at speeds up to 1.3 microns/s, three times faster than the movement of neutrophils in natural conditions.

comparison of microparticles and microrobot

In experiments, scientists used opticaltweezers for precise and active control of the functions that neutrophils perform as part of the immune system. For example, a microrobot moved through the wall of a blood vessel into the surrounding tissue. Another Neutrobot picked up and moved the plastic nanoparticle, demonstrating the potential for drug delivery. And when the microrobot was pushed towards the fragments of red blood cells, he devoured them. At the same time, another neutrophil, which was not controlled by the laser, tried to naturally remove the remaining cells.

Microrobots currently being developed in medicinerequire injections or the use of capsules to introduce them into the animal or human body. But researchers have found that these microscopic objects often trigger immune responses in small animals, leading to the removal of the microrobots from the body before they can do their job. Using cells already present in the body, such as neutrophils, could be a less invasive alternative for drug delivery that doesn't trigger the immune system.

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