Previously, CRISPR genome editing technology was created. However, the problem when changing the genome of cells
Scientists from Tufts University and BroadThe Harvard Institute and the Massachusetts Institute of Technology have developed unique nanoparticles composed of lipids - fat molecules - that can package and deliver gene editing mechanisms specifically to the liver.
In the study, the authors showed that they canuse lipid nanoparticles (LNPS) to efficiently deliver the CRISPR mechanism to the liver of mice. As a result, they can edit genome and level levels to reduce blood levels by 57%.
The problem of obesity is relevant, in particular for the United States,therefore, the authors modified one gene that could provide a protective effect against high cholesterol levels. It inhibits the activity of other enzymes that help break down cholesterol.
The authors tested the development in mice and found that after a single injection of lipid nanoparticles, there was a decrease in cholesterol levels by 57% and triglycerides by about 29%.
This effect persisted for another 100 days.
Physicists have created an analogue of a black hole and confirmed Hawking's theory. Where it leads?
The first panorama of Mars appeared. It consists of 142 photos!
Abortion and science: what will happen to the children who will give birth