Previously, the genome editing technology CRISPR was created. However, the problem when changing the genome of cells
Scientists from Tufts and Broad UniversityInstitute of Harvard and the Massachusetts Institute of Technology have developed unique nanoparticles consisting of lipids - fat molecules - that can package and deliver gene editing machinery specifically to the liver.
In the study, the authors showed that they canuse lipid nanoparticles (LNPS) to efficiently deliver CRISPR machinery to the liver of mice. As a result, they can edit the genome and levels reduce blood levels by 57%.
The problem of obesity is relevant, in particular for the United States,therefore, the authors modified one gene that could provide a protective effect against high cholesterol levels. It inhibits the activity of other enzymes that help break down cholesterol.
The authors tested the development in mice and found that after a single injection of lipid nanoparticles, there was a decrease in cholesterol levels by 57% and triglycerides by about 29%.
This effect persisted for another 100 days.
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