Mice lifespan successfully extended with gene therapy

Researchers from the biotech startup Rejuvenate Bio announced a successful experiment in rejuvenation and...

life extension in mice. The company used gene therapy to add three powerful reprogramming genes to the bodies of mice that were equivalent in age to 77-year-old humans.

According to the company, after processing their remaininglife expectancy has doubled. The treated mice lived an average of 18 more weeks, while the control mice died after nine weeks. Overall, the treated mice lived about 7% longer.

The principle of operation of the technology involvesaffecting mature (old) cells with proteins or genes found in early embryonic stages. This effect rejuvenates the cells, returning them to the stem stage, and is called cell reprogramming.

The authors of the development note that although the increaserelatively small (9 weeks) in the context of the total lifespan of wild mice in the laboratory (2-3 years) is a big result. At the same time, the researchers say that it is too early to draw conclusions about the possibility of using a similar technology in humans: more research is needed on possible side effects, for example, active gene reprogramming can cause cancer.

Much more information is needed tofind out exactly what changes cause reprogramming in mice. The authors of the study hope that the promising result will be repeated in new experiments, and in the future, safe rejuvenation can be applied to people.

Read more:

The strongest class X flare occurred on the Sun

"Anti-cancer sponge" stopped the spread of metastases in 100% of cases

The secret of the durability of Roman concrete is revealed: it can be restored