Migraines and glucose-related symptoms such as fasting insulin and type 2 diabetes are known
“Having identified genetic correlations and common loci andgenes, we established a causal relationship and thus confirmed and improved our understanding of the relationship between migraine, headache and glycemic characteristics,” write the study authors.
“Back in 1935, migraines were described as“glycemic headache. Glycemic traits such as insulin resistance, hyperinsulinemia (too much insulin), hypoglycemia (low blood sugar) and type II diabetes are associated with migraine and headache,” explains Dale Nyholt, Professor at the Center for Genomics and Personalized Health at Queensland University of Technology in Australia.
Now researchers have analyzed the genomesthousands of migraine patients to see if any genetic links can be identified with blood sugar levels. They performed cross-trait analyzes to identify common genomic regions, loci, genes and pathways, and then tested for random relationships.
Thus, scientists observed a genetic correlationfasting insulin and glycosylated hemoglobin with both migraine and headache. “We also found regions that contained genetic risk factors shared by migraine and fasting insulin, fasting glucose, and glycated hemoglobin, and that headache shared regions with glucose, fasting insulin, glycated hemoglobin, and fasting proinsulin,” explain the study authors.
The discovery of genetic links is a step forward in understanding how migraine and associated glycemic symptoms manifest and in the development of new drugs.
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