Researchers at the University of Virginia Medical Center (UVA Health) have developed a method that allows...
Although until now the reasons for the developmentmultiple sclerosis are not fully known, previous studies have shown a relationship between the state of the gut microbiome and this autoimmune reaction. In their study, the researchers showed that the Ah receptor in "barrier tissues" such as the gut influences the development of "harmful inflammation."
In experiments on mice, biologists have blocked inT-lymphocytes (T-cells) the activity of the gene associated with the Ah-receptor. As a result of genetic "reprogramming" in the microbiome of the experimental subjects, compounds such as bile salts and short-chain fatty acids began to form, which hinder the development of T-cells. As a consequence, turning off the receptor led to a reduction in inflammation and recovery in mice.
Multiple sclerosis is an autoimmune diseasea disease caused by T cells that damage the myelin of the central nervous system. This disrupts the transmission of signals between neurons and causes a wide variety of symptoms, including physical, mental and sometimes psychological problems.
So far, there is no cure for this disease, and treatmentaims to help patients manage their symptoms, control flare-ups, and slow the progression of the disease. It is not yet known whether the proposed method will work effectively in humans, but the discovery of the relationship between Ah receptors and the development of multiple sclerosis opens up a new avenue for finding potential drugs.
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