The researchers looked at how primordial germ cells, whose mode of locomotion is similar to other types
The team has developed a new softwaresoftware that allows three-dimensional microscopic images of multiple embryos to be combined to identify patterns in cell distribution. This way you can isolate tissues that affect cell migration.
Using software researchersidentified the domains that cells either avoided, to which they responded by clustering, or in which they retained their normal distribution. Thus, they identified a physical barrier at the border of the body's future spine, where cells change their path.
The researchers used primary germ cells from zebrafish embryos.The paper notes that primary germ cells are the precursors of sperm and eggs: they migrate during the development of many organismsNormally, these cells are controlled by thechemokines, or attractants, produced by surrounding cells that initiate signaling pathways by binding to receptors on primary germ cells.
By genetically modifying the cells, the scientists deactivated the chemokine receptor Cxcr4b so that the cells remained motile, but no longer migrated in a directed manner.
Using new software,The researchers combined microscopic images of hundreds of zebrafish embryos. This allowed them to identify patterns in how primordial germ cells behave in the absence of the Cxr4b attractant receptor. They found that tissue along the longitudinal axis of embryos acts as a physical barrier, influencing the direction of cell movement and inhibiting cell migration through the tissue.
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