Over 100 human proteins interact with coronavirus RNA

Scientists from Germany have identified several genes and variations in DNA, due to which the risk increases by 2-3 times

the likelihood of complications from COVID-19 orpotential lethal outcome. Some of them are responsible for suppressing infections, others play an important role in the reproduction cycle of the virus itself. They are responsible for collecting enzymes that it uses to produce new copies of itself.

In order to understand this, the researchers compiled a list of proteins that interact in one way or another with SARS-CoV-2 particles as they enter human cells.

As a result, it turned out that the coronavirus is soor otherwise interacts with 104 human peptides. As the analysis showed, twenty of them can either suppress or develop the infection. Scientists already knew about some of them, such as EIF4F and EIF4B, from previous experiments.

Scientists paid special attention in their workproteins CNBP and LARP1: they are responsible for the functioning of the built-in immunity and control the circulation of RNA in cells. If you turn off the genes that are responsible for the production of these proteins, SARS-CoV-2 multiplies faster. This means that these molecules can bind to the coronavirus RNA and neutralize it.

The new knowledge, scientists hope, will help in the development of the latest drugs against the virus.

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